Zc3h10 promotes BAT gene expression and protects mice from diet-induced obesity

Whole mount white adipose tissue stained with green lipidTox

Pref-1 is a gate-keeper of adipogenesis

Overview

There are two types of adipose tissue. White adipose tissue (WAT) accumulates triglycerides (TAG) as the main energy storage form. In modern society, obesity from increased WAT mass, with increased TAG storage to enlarge cell size as well as with increased adipocyte number, became a major health problem or disease, especially because of obesity associated diseases, including type 2 diabetes and cardiovascular disease. In contrast to WAT, brown adipose tissue (BAT) dissipates energy as heat via non-shivering thermogenesis. Recent evidence for the presence of functional BAT in human adults has generated considerable interest in BAT as a potential target of obesity prevention/therapeutics. The three broad aims of research in our lab are to understand (1) regulation of TAG synthesis and breakdown, (2) recruitment and differentiation of adipocytes, and (3) relationship between WAT and BAT in regard to their function and development.
 

University of California, Berkeley

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