Viscarra, J.A., Wang, Y., Nguyen, H.P. et al. Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis. Nat Commun 11, 796 (2020). 

Nguyen, H.P., Yi, D., Lin, D., Viscarra, JA.,...Sul, H.S.Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis. Molecular Cell, 77, 1-18.

   Yi, D., Dempersmier, J. M., Nguyen, H. P., Viscarra, J. A., Dinh, J., Tabuchi, C., . . . Sul, H. S. (2019). Zc3h10 Acts as a Transcription Factor and Is Phosphorylated to Activate the Thermogenic Program. Cell Rep, 29(9), 2019.


Gulyaeva O, Nguyen H, Sambeat A, Heydari K, Sul HS. Sox9-Meis1 Inactivation required for Adipogenesis, Advancing Pref-1+ to PDGFRα+ Cells. Cell Reports 25, 1002-1017 2018.

Sambeat A, Gulyaeva O, Dempersmier J, Sul HS. Epigenetic Regulation of Brown adipose tissue program and thermogenesis. Trends Endo. Met. 28, 19-31, 2017.


Viscarra J, Wang Y, Kim S-J, Hong I, Sul HS. Transcriptional activation of de novo fatty acid synthesis by insulin requires MED17 phosphorylation by CK2.  Science Signaling 10, 467, 2017.

 Kim S-J, Tang T, Abbott M, Viscarra JA, Wang Y, Sul HS. AMPK phosphorylates desnutrin/ATGL and HSL to regulate lipolysis and fatty acid oxidation within adipose tissue. Mol. Cell. Biol. 36, 1961-1976, 2016.

Sambeat A, Gulyaeva O, Dempersmier J, Tharp K, Stahl A, Paul SM, Sul HS.  LSD1 interacts with Zfp516 to promote UCP1 transcription and Brown Fat Program. Cell Reports 15, 2536-2549 2016.

Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS. Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat. Mol Cell. 2015 


Perry RJ, Camporez J-PG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Han MS, Zhang X- M, Ruan H-B, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. Hepatic acetyl CoA regulates insulin action and links adipose tissue inflammation with hepatic insulin resistance and type 2 diabetes. Cell 160, 745-758, 2015.

Wang Y, Viscarra JA, Kim, S-J, Sul HS. Transcriptional regulation of lipogenesis. Nat. Rev. Mol. Cell. Biol. 16, 678-689, 2015.

Yi D, Nguyen HP, Sul HS. Epigenetic dynamics of the thermogenic gene program of adipocytes. Biochem J. 2020


Hudak CS, Gulyaeva O, Park SM, Lee L, Kang C, Sul HS. Pref-1 marks early mesenchymal precursors required for adipose tissue development and expansion. Cell Reports 8, 678-687, 2014.


Tang T, Abbott MJ, Ahmadian M, Lopes AB, Wang Y, Sul HS. Desnutrin/ATGL Activates PPARd to Promote Mitochondrial function and Insulin Secretion in Islet b cells. Cell Metabolism 18, 883-895, 2013.

 Wang Y, Wong RH, Tang T, Hudak CS, Yang D, Duncan RE, Sul HS. Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin. Molecular Cell 49, 283-297, 2013.

Yi, D., Nguyen, H.P., Dinh, J. et al. Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes. Elife 2020;9:e59990 DOI: 10.7554/eLife.59990

University of California, Berkeley

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